Publications

MCT1-dependent mitochondrial lactate import sustains cardiac metabolism.

Cluntun AA, Visker JR, Velasco-Silva JN, Carrington J, Cedeño-Rosario L, Napoli GC, Kim JE, Shankar TS, Brothwell MJ, Hamouche R, Narbona-Pérez ÁJ, Ling J, Toshniwal AG, Low HK, Cunningham CN, Eberhardt DR, Li J, Stanley CE, Alcantara QA, Yadav T, Maves RL, Swiatek WI, Offei NA, Blaze B, Shetty SP, Chaudhuri D, Hong T, Rothstein JD, Muoio DM, Paulo JA, Gygi SP, Tseliou E, Navankasattusas S, Cox JE, Funai K, Drakos SG, Rutter J, Ducker GS.

Nature. 2026 Oct 28.

Excessive EFHD1-dependent ER-mitochondrial contacts drive a maladaptive antiviral response in metabolic liver disease.

Eberhardt DR, Rekate EC, Masini YB, Duron HE, Mollinedo D, Velarde AM, Stucki D, Price TR, Lee SH, Balderas E, Rai NK, Bratt AR, Balynas AM, Stubben CJ, Bia R, Maity S, Hartel N, Yin X, Corbin A, Kumari A, Nguyen DM, Shimura D, Nguyen VD, Vinod V, Chowdhury KH, Verdeguer F, Zvick J, Mimche PN, Boudina S, Drakos SG, Aromolaran AS, Franklin S, Garg V, Shaw RM, Holland WL, Summers SA, Pezzolesi MG, Rutter J, Evason KJ, Chaudhuri D.

J Clin Invest. 2026 Sep 1;136(19):e204023.

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer.

Richey A, Kitchen N, Rush CM, Vahrenkamp JM, Abewe H, Osbourne KS, Bott AJ, Dalley BK, Rutter J, Gertz J.

Genome Res. 2026 Sep 1;36(9):1771-1784.

SLC16A6 is a tyrosine transporter for the melanosome.

Cunningham CN, Bott AJ, Adelmann CH, Shields M, Heyden KE, Van Vranken JG, Narbona-Pérez ÁJ, Cantres-Vélez JA, Adelmant G, Krah NM, Gygi SP, Sabatini DM, Rutter J.

bioRxiv [Preprint]. 2026 Jul 7:2026.07.06.736842.

Identification of genomic features that uniquely impact estrogen receptor alpha binding and its effects on gene expression in endometrial cancer.

Richey A, Kitchen N, Rush CM, Vahrenkamp JM, Abewe H, Osbourne KS, Bott AJ, Dalley BK, Rutter J, Gertz J.

bioRxiv [Preprint]. 2026 Jun 29:2025.12.11.693723.

RNA-triggered cell killing with CRISPR-Cas12a2.

Scholz P, Thompson J, Crosby KT, Fauth T, Krah NM, Schlauderaff G, Back R, Berkheimer ZA, Jolley A, Sombroek D, Medert R, Zurek C, Dmytrenko O, Wilson E, Schut FT, Rutter J, Zhang X, Krohn M, Jackson RN, Beisel CL, Liu Y.

Nature. 2026 Jul;655(8121):230-239.

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.

Ziehr DR, Li F, Parnell KM, Krah NM, Leahy KJ, Guillermier C, Gao C, Prell SA, Vigder N, Poli S, Varon J, Baron RM, Maron BA, Philp NJ, Hariri LP, Kim EY, Wei KS, Steinhauser ML, Knipe RS, Rutter J, Oldham WM.

Sci Transl Med. 2026 May 6;18(848):eads2673.

Inhibition of FicD-mediated AMPylation and deAMPylation by isoprenoid diphosphates.

Blevins AM, Peng W, Kinch LN, Monshad Z, Paredes AG, Volz C, Rutter J, Casey AK, Hicks KG, Orth K.

Proc Natl Acad Sci U S A. 2026 Mar 10;123(10):e2533457123.

Excessive Ca2+-dependent ER-mitochondrial contact stabilization by EFHD1 drives liver injury.

Eberhardt DR, Rekate EC, Masini YB, Duron HE, Mollinedo D, Velarde AM, Stucki D, Price T, Lee SHJ, Balderas E, Rai NK, Bratt AR, Balynas AM, Stubben CJ, Bia R, Maity S, Hartel N, Yin X, Corbin A, Kumari A, Nguyen DM, Shimura D, Nguyen VD, Vinod V, Chowdhury KH, Verdeguer F, Zvick J, Mimche PN, Boudina S, Drakos SG, Aromolaran AS, Franklin S, Garg V, Shaw RM, Holland WL, Summers SA, Pezzolesi MG, Rutter J, Evason KJ, Chaudhuri D.

bioRxiv [Preprint]. 2026 Feb 16:2026.02.13.705622.

The fate of pyruvate dictates cell growth by modulating cellular redox potential.

Toshniwal AG, Lam G, Bott AJ, Cluntun AA, Skabelund R, Nam HJ, Wisidagama DR, Thummel CS, Rutter J.

Elife. 2025 Dec 16;13:RP103705.

Systematic metabolite screening identifies functional regulators of the adenosine A2A receptor.

Rao P, Rathinaswamy M, Chan M, Paredes AG, Patel C, Wranik BJ, Powell J, Eaton D, Rutter J, Hicks KG, Mafi A, Hao Q.

Commun Chem. 2025 Dec 9;9(1):19.

Therapeutic remodeling of the ceramide backbone prevents kidney injury.

Nicholson RJ, Cedeño-Rosario L, Maschek JA, Lonergan T, Van Vranken JG, Kruse ARS, Stubben CJ, Wang L, Stuart D, Alcantara QA, Revelo MP, Rutter K, Pahulu M, Taloa J, Wu X, Kim J, Kim J, Hall I, Clark AJ, Parikh S, Spraggins J, Romero D, Blitzer JT, Gygi SP, Rutter J, Holland WL, Ramkumar N, Summers SA.

Cell Metab. 2026 Jan 6;38(1):135-156.e10.

Leveraging genetic and phenotypic variation to discover metabolite-protein interactions.

Ducker GS, Rutter J.

Cell Metab. 2025 Nov 4;37(11):2105-2106.

Progesterone receptor membrane component 1 (PGRMC1) regulates Heme trafficking through mitochondria-ER junctions.

Piel Iii RB, Obi CD, Viana MP, Willoughby MM, Martinez-Guzman O, Wadley A, Jami-Alahmadi Y, Wohlschlegel JA, Hicks KG, Rutter J, Maschek JA, Catrow JL, Cox J, Reddi AR, Khalimonchuk O, Medlock AE.

J Inorg Biochem. 2026 Feb;275:113093.

Gene delivery of AGAT and GAMT boosts creatine levels in creatine transporter deficiency patient fibroblasts.

Wells C, Sorgenfrei J, Johnson SL, Albertson D, Rutter J, Baker SA.

PLoS One. 2025 May 8;20(5):e0319350.

A dual-purification system to isolate mitochondrial subpopulations.

Cunningham CN, Van Vranken JG, Larios J, Heyden K, Gygi SP, Rutter J.

J Cell Sci. 2025 May 1;138(9):jcs263693.

SLC7A5 is required for cancer cell growth under arginine-limited conditions.

Dunlap KN, Bender A, Bowles A, Bott AJ, Tay J, Grossmann AH, Rutter J, Ducker GS.

Cell Rep. 2025 Jan 28;44(1):115130.

Direct mitochondrial import of lactate supports resilient carbohydrate oxidation.

Cluntun AA, Visker JR, Velasco-Silva JN, Lang MJ, Cedeño-Rosario L, Shankar TS, Hamouche R, Ling J, Kim JE, Toshniwal AG, Low HK, Cunningham CN, Carrington J, Catrow JL, Pearce Q, Jeong MY, Bott AJ, Narbona-Pérez ÁJ, Stanley CE, Li Q, Eberhardt DR, Morgan JT, Yadav T, Wells CE, Ramadurai DKA, Swiatek WI, Chaudhuri D, Rothstein JD, Muoio DM, Paulo JA, Gygi SP, Baker SA, Navankasattusas S, Cox JE, Funai K, Drakos SG, Rutter J, Ducker GS.

bioRxiv [Preprint]. 2024 Oct 8:2024.10.07.617073.

The fate of pyruvate dictates cell growth by modulating cellular redox potential.

Toshniwal AG, Lam G, Bott AJ, Cluntun AA, Skabelund R, Nam HJ, Wisidagama DR, Thummel CS, Rutter J.

bioRxiv [Preprint]. 2025 Aug 12:2024.09.23.614588.

Enhancing mitochondrial pyruvate metabolism ameliorates ischemic reperfusion injury in the heart.

Visker JR, Cluntun AA, Velasco-Silva JN, Eberhardt DR, Cedeño-Rosario L, Shankar TS, Hamouche R, Ling J, Kwak H, Hillas JY, Aist I, Tseliou E, Navankasattusas S, Chaudhuri D, Ducker GS, Drakos SG, Rutter J.

JCI Insight. 2024 Jul 25;9(17):e180906.

Lactate transport inhibition therapeutically reprograms fibroblast metabolism in experimental pulmonary fibrosis.

Ziehr DR, Li F, Parnell KM, Krah NM, Leahy KJ, Guillermier C, Varon J, Baron RM, Maron BA, Philp NJ, Hariri LP, Kim EY, Steinhauser ML, Knipe RS, Rutter J, Oldham WM.

bioRxiv [Preprint]. 2024 Apr 28:2024.04.25.591150.

Sedentary behavior in mice induces metabolic inflexibility by suppressing skeletal muscle pyruvate metabolism.

Siripoksup P, Cao G, Cluntun AA, Maschek JA, Pearce Q, Brothwell MJ, Jeong MY, Eshima H, Ferrara PJ, Opurum PC, Mahmassani ZS, Peterlin AD, Watanabe S, Walsh MA, Taylor EB, Cox JE, Drummond MJ, Rutter J, Funai K.

J Clin Invest. 2024 Apr 23;134(11):e167371.

Evaluation of EGFR and COX pathway inhibition in human colon organoids of serrated polyposis and other hereditary cancer syndromes.

Kanth P, Hazel MW, Schell JC, Rutter J, Yao R, Mills AP, Delker DA.

Fam Cancer. 2024 Nov;23(4):479-489.

Phosphate starvation signaling increases mitochondrial membrane potential through respiration-independent mechanisms.

Ouyang Y, Jeong MY, Cunningham CN, Berg JA, Toshniwal AG, Hughes CE, Seiler K, Van Vranken JG, Cluntun AA, Lam G, Winter JM, Akdogan E, Dove KK, Nowinski SM, West M, Odorizzi G, Gygi SP, Dunn CD, Winge DR, Rutter J.

Elife. 2024 Jan 22;13:e84282.

Sexual dimorphism of osteoclast reliance on mitochondrial oxidation of energy substrates in the mouse.

Song C, Valeri A, Song F, Ji X, Liao X, Marmo T, Seeley R, Rutter J, Long F.

JCI Insight. 2023 Dec 22;8(24):e174293.

Integrating the dynamic and energetic fields of metabolism and development.

Finley L, Gendron J, Miguel-Aliaga I, Rutter J.

Development. 2023 Oct 15;150(20):dev202424.

Cardiac gene therapy treats diabetic cardiomyopathy and lowers blood glucose.

Li J, Richmond B, Cluntun AA, Bia R, Walsh MA, Shaw K, Symons JD, Franklin S, Rutter J, Funai K, Shaw RM, Hong T.

JCI Insight. 2023 Sep 22;8(18):e166713.

Ceramides Increase Fatty Acid Utilization in Intestinal Progenitors to Enhance Stemness and Increase Tumor Risk.

Li Y, Chaurasia B, Rahman MM, Kaddai V, Maschek JA, Berg JA, Wilkerson JL, Mahmassani ZS, Cox J, Wei P, Meikle PJ, Atkinson D, Wang L, Poss AM, Playdon MC, Tippetts TS, Mousa EM, Nittayaboon K, Anandh Babu PV, Drummond MJ, Clevers H, Shayman JA, Hirabayashi Y, Holland WL, Rutter J, Edgar BA, Summers SA.

Gastroenterology. 2023 Nov;165(5):1136-1150.

Pyruvate metabolism controls chromatin remodeling during CD4+ T cell activation.

Mocholi E, Russo L, Gopal K, Ramstead AG, Hochrein SM, Vos HR, Geeven G, Adegoke AO, Hoekstra A, van Es RM, Pittol JR, Vastert S, Rutter J, Radstake T, van Loosdregt J, Berkers C, Mokry M, Anderson CC, O'Connell RM, Vaeth M, Ussher J, Burgering BMT, Coffer PJ.

Cell Rep. 2023 Jun 27;42(6):112583.

The secret life of lactate: A novel cell-cycle regulatory mechanism.

Cluntun AA, Rutter J.

Cell Metab. 2023 May 2;35(5):730-732.

Metaboverse enables automated discovery and visualization of diverse metabolic regulatory patterns.

Berg JA, Zhou Y, Ouyang Y, Cluntun AA, Waller TC, Conway ME, Nowinski SM, Van Ry T, George I, Cox JE, Wang B, Rutter J.

Nat Cell Biol. 2023 Apr;25(4):616-625.

Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase.

Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter J.

Science. 2023 Mar 10;379(6636):996-1003.

Recessive pathogenic variants in MCAT cause combined oxidative phosphorylation deficiency.

Webb BD, Nowinski SM, Solmonson A, Ganesh J, Rodenburg RJ, Leandro J, Evans A, Vu HS, Naidich TP, Gelb BD, DeBerardinis RJ, Rutter J, Houten SM.

Elife. 2023 Mar 7;12:e68047.

Transferred mitochondria accumulate reactive oxygen species, promoting proliferation.

Kidwell CU, Casalini JR, Pradeep S, Scherer SD, Greiner D, Bayik D, Watson DC, Olson GS, Lathia JD, Johnson JS, Rutter J, Welm AL, Zangle TA, Roh-Johnson M.

Elife. 2023 Mar 6;12:e85494.

On the cutting edge: perspectives in bioenergetics.

Granath-Panelo M, Krook A, Rutter J, Kajimura S.

Nat Rev Endocrinol. 2023 May;19(5):250-251.

Mitochondrial phosphatidylethanolamine modulates UCP1 to promote brown adipose thermogenesis.

Johnson JM, Peterlin AD, Balderas E, Sustarsic EG, Maschek JA, Lang MJ, Jara-Ramos A, Panic V, Morgan JT, Villanueva CJ, Sanchez A, Rutter J, Lodhi IJ, Cox JE, Fisher-Wellman KH, Chaudhuri D, Gerhart-Hines Z, Funai K.

Sci Adv. 2023 Feb 24;9(8):eade7864.

Metabolites as signalling molecules.

Baker SA, Rutter J.

Nat Rev Mol Cell Biol. 2023 May;24(5):355-374.

Collateral deletion of the mitochondrial AAA+ ATPase ATAD1 sensitizes cancer cells to proteasome dysfunction.

Winter JM, Fresenius HL, Cunningham CN, Wei P, Keys HR, Berg J, Bott A, Yadav T, Ryan J, Sirohi D, Tripp SR, Barta P, Agarwal N, Letai A, Sabatini DM, Wohlever ML, Rutter J.

Elife. 2022 Nov 21;11:e82860.

Intramuscular administration of glyoxylate rescues swine from lethal cyanide poisoning and ameliorates the biochemical sequalae of cyanide intoxication.

Bebarta VS, Shi X, Zheng S, Hendry-Hofer TB, Severance CC, Behymer MM, Boss GR, Mahon S, Brenner M, Knipp GT, Davisson VJ, Peterson RT, MacRae CA, Rutter J, Gerszten RE, Nath AK.

Toxicol Sci. 2023 Jan 31;191(1):90-105.

Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway.

Wei P, Bott AJ, Cluntun AA, Morgan JT, Cunningham CN, Schell JC, Ouyang Y, Ficarro SB, Marto JA, Danial NN, DeBerardinis RJ, Rutter J.

Sci Adv. 2022 Sep 30;8(39):eabq0117.

Stressed to death: Mitochondrial stress responses connect respiration and apoptosis in cancer.

Winter JM, Yadav T, Rutter J.

Mol Cell. 2022 Sep 15;82(18):3321-3332.

Glyoxylate protects against cyanide toxicity through metabolic modulation.

Nielson JR, Nath AK, Doane KP, Shi X, Lee J, Tippetts EG, Saha K, Morningstar J, Hicks KG, Chan A, Zhao Y, Kelly A, Hendry-Hofer TB, Witeof A, Sips PY, Mahon S, Bebarta VS, Davisson VJ, Boss GR, Rutter J, MacRae CA, Brenner M, Gerszten RE, Peterson RT.

Sci Rep. 2022 Mar 23;12(1):4982.

Paradoxical neuronal hyperexcitability in a mouse model of mitochondrial pyruvate import deficiency.

De La Rossa A, Laporte MH, Astori S, Marissal T, Montessuit S, Sheshadri P, Ramos-Fernández E, Mendez P, Khani A, Quairiaux C, Taylor EB, Rutter J, Nunes JM, Carleton A, Duchen MR, Sandi C, Martinou JC.

Elife. 2022 Feb 21;11:e72595.

Protective mitochondrial fission induced by stress-responsive protein GJA1-20k.

Shimura D, Nuebel E, Baum R, Valdez SE, Xiao S, Warren JS, Palatinus JA, Hong T, Rutter J, Shaw RM.

Elife. 2021 Oct 5;10:e69207.

Metabolic decisions in development and disease-a Keystone Symposia report.

Cable J, Pourquié O, Wellen KE, Finley LWS, Aulehla A, Gould AP, Teleman A, Tu WB, Garrett WS, Miguel-Aliaga I, Perrimon N, Hooper LV, Walhout AJM, Wei W, Alexandrov T, Erez A, Ralser M, Rabinowitz JD, Hemalatha A, Gutiérrez-Pérez P, Chandel NS, Rutter J, Locasale JW, Landoni JC, Christofk H.

Ann N Y Acad Sci. 2021 Dec;1506(1):55-73.

The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder.

Nuebel E, Morgan JT, Fogarty S, Winter JM, Lettlova S, Berg JA, Chen YC, Kidwell CU, Maschek JA, Clowers KJ, Argyriou C, Chen L, Wittig I, Cox JE, Roh-Johnson M, Braverman N, Bonkowsky J, Gygi SP, Rutter J.

EMBO Rep. 2021 Oct 5;22(10):e51991.

Sugar phosphate activation of the stress sensor eIF2B.

Hao Q, Heo JM, Nocek BP, Hicks KG, Stoll VS, Remarcik C, Hackett S, LeBon L, Jain R, Eaton D, Rutter J, Wong YL, Sidrauski C.

Nat Commun. 2021 Jun 8;12(1):3440.

Maestro of the SereNADe: SLC25A51 Orchestrates Mitochondrial NAD.

Ouyang Y, Bott AJ, Rutter J.

Trends Biochem Sci. 2021 May;46(5):348-350.

A time to build and a time to burn: glucose metabolism for every season.

McKean WB, Toshniwal AG, Rutter J.

Mol Cell. 2021 Feb 18;81(4):642-644.

Identification of small molecule allosteric modulators of 5,10-methylenetetrahydrofolate reductase (MTHFR) by targeting its unique regulatory domain.

Bezerra GA, Holenstein A, Foster WR, Xie B, Hicks KG, Bürer C, Lutz S, Mukherjee A, Sarkar D, Bhattacharya D, Rutter J, Talukdar A, Brown PJ, Luo M, Shi L, Froese DS, Yue WW.

Biochimie. 2021 Apr;183:100-107.

The pyruvate-lactate axis modulates cardiac hypertrophy and heart failure.

Cluntun AA, Badolia R, Lettlova S, Parnell KM, Shankar TS, Diakos NA, Olson KA, Taleb I, Tatum SM, Berg JA, Cunningham CN, Van Ry T, Bott AJ, Krokidi AT, Fogarty S, Skedros S, Swiatek WI, Yu X, Luo B, Merx S, Navankasattusas S, Cox JE, Ducker GS, Holland WL, McKellar SH, Rutter J, Drakos SG.

Cell Metab. 2021 Mar 2;33(3):629-648.e10.

Publisher Correction: Mitochondrial pyruvate carriers are required for myocardial stress adaptation.

Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED.

Nat Metab. 2020 Dec;2(12):1498.

Callyspongiolide Is a Potent Inhibitor of the Vacuolar ATPase.

Fogarty S, Ouyang Y, Li L, Chen YC, Rane H, Manoni F, Parra KJ, Rutter J, Harran PG.

J Nat Prod. 2020 Nov 25;83(11):3381-3386.

Mitochondrial pyruvate carriers are required for myocardial stress adaptation.

Zhang Y, Taufalele PV, Cochran JD, Robillard-Frayne I, Marx JM, Soto J, Rauckhorst AJ, Tayyari F, Pewa AD, Gray LR, Teesch LM, Puchalska P, Funari TR, McGlauflin R, Zimmerman K, Kutschke WJ, Cassier T, Hitchcock S, Lin K, Kato KM, Stueve JL, Haff L, Weiss RM, Cox JE, Rutter J, Taylor EB, Crawford PA, Lewandowski ED, Des Rosiers C, Abel ED.

Nat Metab. 2020 Nov;2(11):1248-1264.

Chronic cold exposure enhances glucose oxidation in brown adipose tissue.

Wang Z, Ning T, Song A, Rutter J, Wang QA, Jiang L.

EMBO Rep. 2020 Nov 5;21(11):e50085.

Mitochondrial fatty acid synthesis coordinates oxidative metabolism in mammalian mitochondria.

Nowinski SM, Solmonson A, Rusin SF, Maschek JA, Bensard CL, Fogarty S, Jeong MY, Lettlova S, Berg JA, Morgan JT, Ouyang Y, Naylor BC, Paulo JA, Funai K, Cox JE, Gygi SP, Winge DR, DeBerardinis RJ, Rutter J.

Elife. 2020 Aug 17;9:e58041.

Mitochondrial pyruvate carrier is required for optimal brown fat thermogenesis.

Panic V, Pearson S, Banks J, Tippetts TS, Velasco-Silva JN, Lee S, Simcox J, Geoghegan G, Bensard CL, van Ry T, Holland WL, Summers SA, Cox J, Ducker GS, Rutter J, Villanueva CJ.

Elife. 2020 Aug 14;9:e52558.

Crystal structure and interaction studies of human DHTKD1 provide insight into a mitochondrial megacomplex in lysine catabolism.

Bezerra GA, Foster WR, Bailey HJ, Hicks KG, Sauer SW, Dimitrov B, McCorvie TJ, Okun JG, Rutter J, Kölker S, Yue WW.

IUCrJ. 2020 Jun 10;7(Pt 4):693-706.

Validation of PAS Kinase, a Regulator of Hepatic Fatty Acid and Triglyceride Synthesis, as a Therapeutic Target for Nonalcoholic Steatohepatitis.

Swiatek W, Parnell KM, Nickols GA, Scharschmidt BF, Rutter J.

Hepatol Commun. 2020 Mar 24;4(5):696-707.

The Role of Nonglycolytic Glucose Metabolism in Myocardial Recovery Upon Mechanical Unloading and Circulatory Support in Chronic Heart Failure.

Badolia R, Ramadurai DKA, Abel ED, Ferrin P, Taleb I, Shankar TS, Krokidi AT, Navankasattusas S, McKellar SH, Yin M, Kfoury AG, Wever-Pinzon O, Fang JC, Selzman CH, Chaudhuri D, Rutter J, Drakos SG.

Circulation. 2020 Jul 21;142(3):259-274.

20,000 picometers under the OMM: diving into the vastness of mitochondrial metabolite transport.

Cunningham CN, Rutter J.

EMBO Rep. 2020 May 6;21(5):e50071.

T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation.

Ekiz HA, Ramstead AG, Lee SH, Nelson MC, Bauer KM, Wallace JA, Hu R, Round JL, Rutter J, Drummond MJ, Rao DS, O'Connell RM.

J Immunol. 2020 Apr 15;204(8):2064-2075.

Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development.

Ramstead AG, Wallace JA, Lee SH, Bauer KM, Tang WW, Ekiz HA, Lane TE, Cluntun AA, Bettini ML, Round JL, Rutter J, O'Connell RM.

Cell Rep. 2020 Mar 3;30(9):2889-2899.e6.

Reign in the membrane: How common lipids govern mitochondrial function.

Funai K, Summers SA, Rutter J.

Curr Opin Cell Biol. 2020 Apr;63:162-173.

XPRESSyourself: Enhancing, standardizing, and automating ribosome profiling computational analyses yields improved insight into data.

Berg JA, Belyeu JR, Morgan JT, Ouyang Y, Bott AJ, Quinlan AR, Gertz J, Rutter J.

PLoS Comput Biol. 2020 Jan 31;16(1):e1007625.

Compartment and hub definitions tune metabolic networks for metabolomic interpretations.

Waller TC, Berg JA, Lex A, Chapman BE, Rutter J.

Gigascience. 2020 Jan 1;9(1):giz137.

Regulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier.

Bensard CL, Wisidagama DR, Olson KA, Berg JA, Krah NM, Schell JC, Nowinski SM, Fogarty S, Bott AJ, Wei P, Dove KK, Tanner JM, Panic V, Cluntun A, Lettlova S, Earl CS, Namnath DF, Vázquez-Arreguín K, Villanueva CJ, Tantin D, Murtaugh LC, Evason KJ, Ducker GS, Thummel CS, Rutter J.

Cell Metab. 2020 Feb 4;31(2):284-300.e7.

Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity.

Heden TD, Johnson JM, Ferrara PJ, Eshima H, Verkerke ARP, Wentzler EJ, Siripoksup P, Narowski TM, Coleman CB, Lin CT, Ryan TE, Reidy PT, de Castro Brás LE, Karner CM, Burant CF, Maschek JA, Cox JE, Mashek DG, Kardon G, Boudina S, Zeczycki TN, Rutter J, Shaikh SR, Vance JE, Drummond MJ, Neufer PD, Funai K.

Sci Adv. 2019 Sep 11;5(9):eaax8352.

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.

Science. 2019 Jul 26;365(6451):386-392.

Activation of PASK by mTORC1 is required for the onset of the terminal differentiation program.

Kikani CK, Wu X, Fogarty S, Kang SAW, Dephoure N, Gygi SP, Sabatini DM, Rutter J.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10382-10391.

Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.

Vázquez-Arreguín K, Bensard C, Schell JC, Swanson E, Chen X, Rutter J, Tantin D.

PLoS Genet. 2019 May 6;15(5):e1007687.

Impact of Mitochondrial Fatty Acid Synthesis on Mitochondrial Biogenesis.

Nowinski SM, Van Vranken JG, Dove KK, Rutter J.

Curr Biol. 2018 Oct 22;28(20):R1212-R1219.

ACP Acylation Is an Acetyl-CoA-Dependent Modification Required for Electron Transport Chain Assembly.

Van Vranken JG, Nowinski SM, Clowers KJ, Jeong MY, Ouyang Y, Berg JA, Gygi JP, Gygi SP, Winge DR, Rutter J.

Mol Cell. 2018 Aug 16;71(4):567-580.e4.

Identification of specific metabolic pathways as druggable targets regulating the sensitivity to cyanide poisoning.

Sips PY, Shi X, Musso G, Nath AK, Zhao Y, Nielson J, Morningstar J, Kelly AE, Mikell B, Buys E, Bebarta V, Rutter J, Davisson VJ, Mahon S, Brenner M, Boss GR, Peterson RT, Gerszten RE, MacRae CA.

PLoS One. 2018 Jun 7;13(6):e0193889.

Vms1p is a release factor for the ribosome-associated quality control complex.

Zurita Rendón O, Fredrickson EK, Howard CJ, Van Vranken J, Fogarty S, Tolley ND, Kalia R, Osuna BA, Shen PS, Hill CP, Frost A, Rutter J.

Nat Commun. 2018 Jun 6;9(1):2197.

The Force Is Strong with This One: Metabolism (Over)powers Stem Cell Fate.

Wei P, Dove KK, Bensard C, Schell JC, Rutter J.

Trends Cell Biol. 2018 Jul;28(7):551-559.

Lipid-mediated signals that regulate mitochondrial biology.

Nielson JR, Rutter JP.

J Biol Chem. 2018 May 18;293(20):7517-7521.

Sterol Oxidation Mediates Stress-Responsive Vms1 Translocation to Mitochondria.

Nielson JR, Fredrickson EK, Waller TC, Rendón OZ, Schubert HL, Lin Z, Hill CP, Rutter J.

Mol Cell. 2017 Nov 16;68(4):673-685.e6.

Loss of p16INK4A stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway.

Tyagi E, Liu B, Li C, Liu T, Rutter J, Grossman D.

Oncotarget. 2017 Aug 3;8(34):55848-55862.

Global Analysis of Plasma Lipids Identifies Liver-Derived Acylcarnitines as a Fuel Source for Brown Fat Thermogenesis.

Simcox J, Geoghegan G, Maschek JA, Bensard CL, Pasquali M, Miao R, Lee S, Jiang L, Huck I, Kershaw EE, Donato AJ, Apte U, Longo N, Rutter J, Schreiber R, Zechner R, Cox J, Villanueva CJ.

Cell Metab. 2017 Sep 5;26(3):509-522.e6.

Control of intestinal stem cell function and proliferation by mitochondrial pyruvate metabolism.

Schell JC, Wisidagama DR, Bensard C, Zhao H, Wei P, Tanner J, Flores A, Mohlman J, Sorensen LK, Earl CS, Olson KA, Miao R, Waller TC, Delker D, Kanth P, Jiang L, DeBerardinis RJ, Bronner MP, Li DY, Cox JE, Christofk HR, Lowry WE, Thummel CS, Rutter J.

Nat Cell Biol. 2017 Sep;19(9):1027-1036.

Lactate dehydrogenase activity drives hair follicle stem cell activation.

Flores A, Schell J, Krall AS, Jelinek D, Miranda M, Grigorian M, Braas D, White AC, Zhou JL, Graham NA, Graeber T, Seth P, Evseenko D, Coller HA, Rutter J, Christofk HR, Lowry WE.

Nat Cell Biol. 2017 Sep;19(9):1017-1026.

EWS/FLI is a Master Regulator of Metabolic Reprogramming in Ewing Sarcoma.

Tanner JM, Bensard C, Wei P, Krah NM, Schell JC, Gardiner J, Schiffman J, Lessnick SL, Rutter J.

Mol Cancer Res. 2017 Nov;15(11):1517-1530.

Structure of human Fe-S assembly subcomplex reveals unexpected cysteine desulfurase architecture and acyl-ACP-ISD11 interactions.

Cory SA, Van Vranken JG, Brignole EJ, Patra S, Winge DR, Drennan CL, Rutter J, Barondeau DP.

Proc Natl Acad Sci U S A. 2017 Jul 3;114(27):E5325-E5334.

Mitochondria link metabolism and epigenetics in haematopoiesis.

Schell JC, Rutter J.

Nat Cell Biol. 2017 May 31;19(6):589-591.

Evidence of Glycolysis Up-Regulation and Pyruvate Mitochondrial Oxidation Mismatch During Mechanical Unloading of the Failing Human Heart: Implications for Cardiac Reloading and Conditioning.

Diakos NA, Navankasattusas S, Abel ED, Rutter J, McCreath L, Ferrin P, McKellar SH, Miller DV, Park SY, Richardson RS, Deberardinis R, Cox JE, Kfoury AG, Selzman CH, Stehlik J, Fang JC, Li DY, Drakos SG.

JACC Basic Transl Sci. 2016 Oct;1(6):432-444.

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC).

Sandoval IT, Delacruz RG, Miller BN, Hill S, Olson KA, Gabriel AE, Boyd K, Satterfield C, Van Remmen H, Rutter J, Jones DA.

Elife. 2017 Apr 11;6:e22706.

Quality control and organelle trafficking: ensuring functional organelles and cells.

Brill JA, Rutter J.

Mol Biol Cell. 2017 Mar 15;28(6):701-702.

Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis.

Kikani CK, Wu X, Paul L, Sabic H, Shen Z, Shakya A, Keefe A, Villanueva C, Kardon G, Graves B, Tantin D, Rutter J.

Elife. 2016 Sep 23;5:e17985.

The Whole (Cell) Is Less Than the Sum of Its Parts.

Van Vranken JG, Rutter J.

Cell. 2016 Aug 25;166(5):1078-1079.

The mitochondrial acyl carrier protein (ACP) coordinates mitochondrial fatty acid synthesis with iron sulfur cluster biogenesis.

Van Vranken JG, Jeong MY, Wei P, Chen YC, Gygi SP, Winge DR, Rutter J.

Elife. 2016 Aug 19;5:e17828.

You Are What You Eat... or Are You?

Tanner JM, Rutter J.

Dev Cell. 2016 Mar 7;36(5):483-5.

Pyruvate and Metabolic Flexibility: Illuminating a Path Toward Selective Cancer Therapies.

Olson KA, Schell JC, Rutter J.

Trends Biochem Sci. 2016 Mar;41(3):219-230.

Hepatic Mitochondrial Pyruvate Carrier 1 Is Required for Efficient Regulation of Gluconeogenesis and Whole-Body Glucose Homeostasis.

Gray LR, Sultana MR, Rauckhorst AJ, Oonthonpan L, Tompkins SC, Sharma A, Fu X, Miao R, Pewa AD, Brown KS, Lane EE, Dohlman A, Zepeda-Orozco D, Xie J, Rutter J, Norris AW, Cox JE, Burgess SC, Potthoff MJ, Taylor EB.

Cell Metab. 2015 Oct 6;22(4):669-81.

You Down With ETC? Yeah, You Know D!

Van Vranken JG, Rutter J.

Cell. 2015 Jul 30;162(3):471-3.

Power(2): the power of yeast genetics applied to the powerhouse of the cell.

Rutter J, Hughes AL.

Trends Endocrinol Metab. 2015 Feb;26(2):59-68.

Glutamine oxidation maintains the TCA cycle and cell survival during impaired mitochondrial pyruvate transport.

Yang C, Ko B, Hensley CT, Jiang L, Wasti AT, Kim J, Sudderth J, Calvaruso MA, Lumata L, Mitsche M, Rutter J, Merritt ME, DeBerardinis RJ.

Mol Cell. 2014 Nov 6;56(3):414-424.

A role for the mitochondrial pyruvate carrier as a repressor of the Warburg effect and colon cancer cell growth.

Schell JC, Olson KA, Jiang L, Hawkins AJ, Van Vranken JG, Xie J, Egnatchik RA, Earl EG, DeBerardinis RJ, Rutter J.

Mol Cell. 2014 Nov 6;56(3):400-413.

PAS kinase drives lipogenesis through SREBP-1 maturation.

Wu X, Romero D, Swiatek WI, Dorweiler I, Kikani CK, Sabic H, Zweifel BS, McKearn J, Blitzer JT, Nickols GA, Rutter J.

Cell Rep. 2014 Jul 10;8(1):242-55.

The LYR factors SDHAF1 and SDHAF3 mediate maturation of the iron-sulfur subunit of succinate dehydrogenase.

Na U, Yu W, Cox J, Bricker DK, Brockmann K, Rutter J, Thummel CS, Winge DR.

Cell Metab. 2014 Aug 5;20(2):253-66.

SDHAF4 promotes mitochondrial succinate dehydrogenase activity and prevents neurodegeneration.

Van Vranken JG, Bricker DK, Dephoure N, Gygi SP, Cox JE, Thummel CS, Rutter J.

Cell Metab. 2014 Aug 5;20(2):241-52.

Msp1/ATAD1 maintains mitochondrial function by facilitating the degradation of mislocalized tail-anchored proteins.

Chen YC, Umanah GK, Dephoure N, Andrabi SA, Gygi SP, Dawson TM, Dawson VL, Rutter J.

EMBO J. 2014 Jul 17;33(14):1548-64.

Pressing mitochondrial genetics forward.

Chen YC, Rutter J.

Cell Rep. 2014 May 8;7(3):599-600.

The long and winding road to the mitochondrial pyruvate carrier.

Schell JC, Rutter J.

Cancer Metab. 2013 Jan 23;1(1):6.

Intramolecular interactions control Vms1 translocation to damaged mitochondria.

Heo JM, Nielson JR, Dephoure N, Gygi SP, Rutter J.

Mol Biol Cell. 2013 May;24(9):1263-73.

A mitochondrial pyruvate carrier required for pyruvate uptake in yeast, Drosophila, and humans.

Bricker DK, Taylor EB, Schell JC, Orsak T, Boutron A, Chen YC, Cox JE, Cardon CM, Van Vranken JG, Dephoure N, Redin C, Boudina S, Gygi SP, Brivet M, Thummel CS, Rutter J.

Science. 2012 Jul 6;337(6090):96-100.

Proliferation and metabolism: it's as easy as APC.

Tantin D, Rutter J.

Cell Metab. 2012 Apr 4;15(4):413-4.

Identification of a protein mediating respiratory supercomplex stability.

Chen YC, Taylor EB, Dephoure N, Heo JM, Tonhato A, Papandreou I, Nath N, Denko NC, Gygi SP, Rutter J.

Cell Metab. 2012 Mar 7;15(3):348-60.

PAS kinase promotes cell survival and growth through activation of Rho1.

Cardon CM, Beck T, Hall MN, Rutter J.

Sci Signal. 2012 Jan 31;5(209):ra9.

PAS kinase: integrating nutrient sensing with nutrient partitioning.

Cardon CM, Rutter J.

Semin Cell Dev Biol. 2012 Aug;23(6):626-30.

Revealing the allosterome: systematic identification of metabolite-protein interactions.

Orsak T, Smith TL, Eckert D, Lindsley JE, Borges CR, Rutter J.

Biochemistry. 2012 Jan 10;51(1):225-32.

Human mutation within Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) causes basal insulin hypersecretion.

Semplici F, Vaxillaire M, Fogarty S, Semache M, Bonnefond A, Fontés G, Philippe J, Meur G, Diraison F, Sessions RB, Rutter J, Poitout V, Froguel P, Rutter GA.

J Biol Chem. 2011 Dec 23;286(51):44005-44014.

Mitochondrial quality control by the ubiquitin-proteasome system.

Taylor EB, Rutter J.

Biochem Soc Trans. 2011 Oct;39(5):1509-13.

Ubiquitin-dependent mitochondrial protein degradation.

Heo JM, Rutter J.

Int J Biochem Cell Biol. 2011 Oct;43(10):1422-6.

A stress-responsive system for mitochondrial protein degradation.

Heo JM, Livnat-Levanon N, Taylor EB, Jones KT, Dephoure N, Ring J, Xie J, Brodsky JL, Madeo F, Gygi SP, Ashrafi K, Glickman MH, Rutter J.

Mol Cell. 2010 Nov 12;40(3):465-80.

Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation.

Kikani CK, Antonysamy SA, Bonanno JB, Romero R, Zhang FF, Russell M, Gheyi T, Iizuka M, Emtage S, Sauder JM, Turk BE, Burley SK, Rutter J.

J Biol Chem. 2010 Dec 24;285(52):41034-43.

Succinate dehydrogenase - Assembly, regulation and role in human disease.

Rutter J, Winge DR, Schiffman JD.

Mitochondrion. 2010 Jun;10(4):393-401.

SDH5, a gene required for flavination of succinate dehydrogenase, is mutated in paraganglioma.

Hao HX, Khalimonchuk O, Schraders M, Dephoure N, Bayley JP, Kunst H, Devilee P, Cremers CW, Schiffman JD, Bentz BG, Gygi SP, Winge DR, Kremer H, Rutter J.

Science. 2009 Aug 28;325(5944):1139-42.

Regulation and function of yeast PAS kinase: a role in the maintenance of cellular integrity.

Grose JH, Sundwall E, Rutter J.

Cell Cycle. 2009 Jun 15;8(12):1824-32.

Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases.

Beumer KJ, Trautman JK, Bozas A, Liu JL, Rutter J, Gall JG, Carroll D.

Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19821-6.

The role of PAS kinase in regulating energy metabolism.

Hao HX, Rutter J.

IUBMB Life. 2008 Apr;60(4):204-9.

Yeast PAS kinase coordinates glucose partitioning in response to metabolic and cell integrity signaling.

Grose JH, Smith TL, Sabic H, Rutter J.

EMBO J. 2007 Nov 28;26(23):4824-30.

PAS kinase is required for normal cellular energy balance.

Hao HX, Cardon CM, Swiatek W, Cooksey RC, Smith TL, Wilde J, Boudina S, Abel ED, McClain DA, Rutter J.

Proc Natl Acad Sci U S A. 2007 Sep 25;104(39):15466-71.

Regulation of glucose partitioning by PAS kinase and Ugp1 phosphorylation.

Smith TL, Rutter J.

Mol Cell. 2007 May 25;26(4):491-9.

Whence cometh the allosterome?

Lindsley JE, Rutter J.

Proc Natl Acad Sci U S A. 2006 Jul 11;103(28):10533-5.

Control of mammalian glycogen synthase by PAS kinase.

Wilson WA, Skurat AV, Probst B, de Paoli-Roach A, Roach PJ, Rutter J.

Proc Natl Acad Sci U S A. 2005 Nov 15;102(46):16596-601.

Nutrient sensing and metabolic decisions.

Lindsley JE, Rutter J.

Comp Biochem Physiol B Biochem Mol Biol. 2004 Dec;139(4):543-59.